Arabinoxylan (hereafter called MGN-3) (also known as Lentin Plus 1000) is a plant polysaccharide processed food with a biophylactic action, which mainly contains polysaccharides such as hemicellulose and arabinoxylan and glycoprotein. MGN-3 is known to have various biophylactic actions such as in vitro NK cell activity stimulation and anti-HIV effect. In the present study, the vital defense activating effect of MGN-3 was studied in 3 animal experiments: Experiment 1 examined its effect on the survival in a lipopolysaccharide-induced lethal sepsis model, Experiment 2 studied the anti-stress effect on restraint stress, and Experiment 3 examined its effect on the survival of autoimmune disease-prone (NZB ><NZW) F1 mice.
PEER REVIEWED
The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence
Nobuyuki Sudo, Konen Tatoe, Naomi Koyama, Hideyuki Kanna, Kenji Hirayama, and Chiharu Kubo | (edited by Chris Gutch PhD.) | 2001
Proven Results, Backed by Clinical Research
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Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran
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PEER REVIEWEDBasophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran
2025Background and Objectives: MGN-3/Biobran (BRM4, Lentin Plus 1000 or Ribraxx) is a natural, rice bran-derived arabinoxylan immunoceutical that modulates the adaptive immune response to viral infections. In response to bacterial...
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Biobran/MGN-3: A Promising Natural Strategy for Mitigating Kidney Damage and Immune Modulation During Etoposide Therapy
Although chemotherapy is one of the pillars in cancer treatment, its side effects have extremely harmful impacts on many of the body's organs. This study investigates the potential protective effect...
Biobran/MGN-3: A Promising Natural Strategy for Mitigating Kidney Damage and Immune Modulation During Etoposide Therapy
2025Although chemotherapy is one of the pillars in cancer treatment, its side effects have extremely harmful impacts on many of the body's organs. This study investigates the potential protective effect...
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Nanoparticle Enhanced. The Protective Effects of MGN-3 BioBran Against Ehrlich Ascites Carcinoma-Induced Toxicity in the Liver, Kidneys and Spleen of Mice
Background: Nanoparticle-enabled targeted drug delivery has proven effective in cancer treatment due to its ability to cross biological barriers, achieve therapeutic concentrations within tumors, and minimize adverse effects on surrounding...
Nanoparticle Enhanced. The Protective Effects of MGN-3 BioBran Against Ehrlich Ascites Carcinoma-Induced Toxicity in the Liver, Kidneys and Spleen of Mice
2025Background: Nanoparticle-enabled targeted drug delivery has proven effective in cancer treatment due to its ability to cross biological barriers, achieve therapeutic concentrations within tumors, and minimize adverse effects on surrounding...
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